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Multiple mio10s, what´s the best connection option?

I´m rebuilding the studio and decided to replace 6 MIDI Timepieces and 4 Opcode 8ports with mio10s. It was a cascaded star setup, sometimes 3 patchbays between device and DAW - this had to go. Now I wonder what the ideal connection looks like (latency/timing): OPTION A: non-USB, ethernet-only, so 64 channels per mio10 (which is ok) and no more USB hassle (win10) // OPTION B: USB only with all mio10 on a single powered hub OPTION C: same as B but using multiple hubs OPTION D: ethernet-usb mix? My main concern is timing.
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